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. 2017 Sep 21;12(9):e0184843. doi: 10.1371/journal.pone.0184843

Fig 5. PF-06928215 is a high affinity cGAS inhibitor.

Fig 5

(A) Concentration-dependent inhibition in cGAMP FP assay. (B) SPR sensorgram of PF-06928215 binding to cGAS, 2-fold variations in the concentration of PF-06928215 are shown in rainbow registry with kinetic association and dissociation fits in black. (C) cGAS active site showing residues that interact with PF-06928215, Fo-Fc electron density omit map (green) for PF-06928215 (brown) is contoured at 3 Sigma and shows all density within 4 Å of PF-06928215. Figure was generated using Pymol.