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. 2017 Sep 21;12(9):e0184697. doi: 10.1371/journal.pone.0184697

Table 1. Biologically relevant triplets.

By tracing statistically significant triplets in the enriched terms, 12 triplets in which X1 and X2 are involved in the same biological process or pathway were determined.

GO Term GO Levels p-value FDR (BH) Triplet Number
Biological Process Regulation of immune system process [2, 3] 1.13E-05 5.20E-03 34,72,90
Defense response [3] 2.15E-04 6.20E-03 34
Response to other organism [2, 4] 3.32E-04 9.01E-03 34
Regulation of defense response [4, 5] 9.20E-04 1.21E-02 34
Cytokine production [3] 7.46E-04 1.23E-02 78
Negative regulation of apoptotic signaling pathway [4, 5, 6, 7, 8] 1.24E-03 1.50E-02 22
Regulation of response to stimulus [2, 3] 1.28E-03 1.52E-02 22,29,34
Positive regulation of cellular metabolic process [3, 4, 5] 1.46E-03 1.64E-02 34,45
Cellular response to chemical stimulus [3] 1.91E-03 1.80E-02 34,38,22
Regulation of response to external stimulus [3, 4] 1.76E-03 1.81E-02 34
Cellular response to hydrogen peroxide [5, 6] 2.89E-03 2.30E-02 34
Programmed cell death [4] 3.27E-03 2.48E-02 34,22
Negative regulation of apoptotic process [5, 6, 7] 5.06E-03 3.16E-02 22,34
Regulation of apoptotic signaling pathway [4, 5, 6, 7] 5.58E-03 3.30E-02 22
Positive regulation of biological process [1, 2, 3] 7.43E-03 3.90E-02 34,45,60,90
Positive regulation of metabolic process [2, 3, 4] 8.37E-03 4.16E-02 34,45
Positive regulation of macromolecule metabolic process [3, 4, 5] 8.60E-03 4.23E-02 45
Cellular response to oxygen-containing compound [4] 9.06E-03 4.27E-02 34
Cell surface receptor signaling pathway [4, 5] 1.00E-02 4.64E-02 46
Positive regulation of cellular process [2, 3, 4] 1.15E-02 5.18E-02 34,45,90
Regulation of apoptotic process [5, 6] 1.35E-02 5.68E-02 22,34
Oxidation-reduction process [3] 1.53E-02 5.94E-02 38
Negative regulation of cell proliferation [3, 4, 5] 1.50E-02 5.98E-02 88
Response to wounding [3] 1.59E-02 6.11E-02 60
Apoptotic signaling pathway [4, 5, 6] 1.61E-02 6.11E-02 22
Regulation of protein metabolic process [4, 5] 1.82E-02 6.66E-02 34
Regulation of response to stress [3, 4] 2.04E-02 7.09E-02 34
Regulation of signal transduction [3, 4, 5] 2.52E-02 8.01E-02 22
Response to oxygen-containing compound [3] 2.67E-02 8.34E-02 34
Single-organism transport [3, 4] 3.02E-02 8.83E-02 72
Transport [3] 3.34E-02 9.24E-02 72
Pathway Immune System 9.80E-04 3.82E-02 11,90
Adaptive Immune System 8.02E-04 4.69E-02 11