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. 2017 Sep 21;12(9):e0184891. doi: 10.1371/journal.pone.0184891

Fig 3. Analysis of SOX2 and OCT4 expression in osteosarcoma cells treated with chemotherapy agents.

Fig 3

A. Correlation between presence of metastasis in osteosarcoma patients and SOX2 expression in cells derived from their tumors. B. Western blot analysis of SOX2 and OCT4 expression in primary tumor cells directly isolated from osteosarcoma patients (OS1 and OS6) before (PRE) and after (POST) chemotherapy treatments. Cyclophilin B was used as loading control. C. Western blot analysis of SOX2 and OCT4 expression in primary tumor cells (OS1 and OS9) after in vitro treatment with cisplatin, doxorubicin or methotrexate. * P < 0.05, ** P < 0.01, Mann-Whitney U test.