Table 2. Histological tumor type, chemotherapeutic agents adopted, Huvos grade, alkaline phosphatase values (ALP), percentage of SOX2+ cells, relapse, presence of metastasis, and anatomic site of metastasis.
| Sample ID | Histological Type | CH | Histological response (Huvos Grade) | ALP value above reference | % of SOX2+ cells >10% | Relapse | Metastasis | Death | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| at diagnosis | after/during treatment | Anatomic Site | Months after diagnosis | Months after CH | |||||||
| OS01 | Conventional Central OS | Dox, Cis, MTX | II | 2.4 | 2.7 | yes | yes | lung | 20.4 | 19.6 | yes |
| OS02 | Conventional Central OS | Dox, Cis | II | 1.4 | 0.7 | yes | yes | axillary lymph node | 18.0 | 16.9 | yes |
| OS03 | Conventional Central OS | Dox, Cis, MTX, Ifo | II | 0.6 | 0.5 | no | no | lung | 1.9 | 0.8 | yes |
| OS04 | Conventional Central OS | Dox, Cis, MTX | not performed | 1.0 | 0.6 | no | no | not applied | no | no | yes |
| OS05 | Conventional Central OS | Dox, MTX,Cis, Eto, Ifo | II | 1.0 | 0.5 | no | no | not applied | no | no | no |
| OS06 | Telangiectasic OS | Dox, Cis, Manitol, MTX | I | 1.3 | 1.1 | yes | no | lung | 4.7 | 3.4 | no |
| OS07 | Conventional Central OS | Dox, Cis, MTX | IV | 0.8 | 0.8 | no | no | not applied | no | no | no |
| OS08 | Conventional Central OS | Dox, Cis, MTX | II | 0.6 | 1.0 | yes | no | lung | 7.5 | 6.8 | no |
| OS09 | Conventional Central OS | Dox, Cis, MTX, Eto, Ifo | II | 1.7 | 1.0 | no | no | lung, brain | 11.3 | 10.2 | no |
| OS10 | Conventional Central OS | Dox, Cis, Ifo | not performed | 0.8 | 0.8 | no | no | lung | 0.5 | before CH | yes |
| OS11 | Telangiectasic OS | Dox, Cis, MTX | IV | 0.2 | 0.1 | no | no | not applied | no | no | no |
| OS12 | Conventional Central OS | Dox, Cis, MTX, ETO, IFO | III | 2.2 | 0.5 | no | no | lung | 13.5 | 12.1 | no |
| OS13 | Conventional Central OS | Dox, Cis, MTX | III | 0.4 | 0.7 | no | no | not applied | no | no | no |
| OS14 | Pleomorphic Central OS | Cis, Dox, Ifo, Eto | not accessed | 0.7 | 0.4 | no | no | lung | when first seen | before CH | no |
| OS15 | Telangiectasic OS | Dox, Cis, MTX | II | 0.7 | 0.8 | yes | no | lung | 3.5 | 5.8 | no |
| OS16 | Conventional Central OS | Dox, MTX,Cis, Eto, Ifo | II | 1.0 | 0.8 | no | no | lung | 8.9 | 7.6 | no |
| OS17 | Conventional Central OS | Dox, Cis, Ifo | not performed | 25.0 | not performed | yes | no | lung, axillary lymph node | 10.9 | 10.7 | yes |
| OS18 | Conventional Central OS | Cis, Dox, MTX | I | not performed | not performed | no | no | not applied | no | no | no |
| OS19 | Conventional Central OS | Dox, Cis | not performed | 1.2 | 0.6 | no | no | not applied | no | no | no |
| OS20 | Telangiectasic OS | Dox, Cis, MTX | I | 0.7 | not accessed | no | no | lung | 2.9 | 2.6 | yes |
| OS21 | Chondroblastic OS | Dox, Cis, Ifo | not performed | 0.8 | 0.6 | no | no | lung | 30 | 29 | no |
| OS22 | Conventional Central OS | Dox, Cis, MTX | not performed | 1.5 | 1.0 | no | no | not applied | no | no | no |
| OS23 | Conventional Central OS | Cis, Dox, MTX | III | 0.4 | 0.5 | no | no | lung | 0.8 | before CH | no |
| OS24 | Conventional Central OS | Dox, Cis, MTX, Eto | not performed | not accessed | 0.6 | no | no | lung, costal arch | 0.9 | 0.3 | yes |
| OS25 | Conventional Central OS | Dox, Cis, Ifo | II | 0.7 | 0.4 | yes | no | lung | 12.4 | 6.8 | no |
| OS26 | Conventional Central OS | Dox, MTX,CIS, Manitol, ETO, IFO | III | 0.7 | 0.8 | yes | no | lung | 2.7 | 4.2 | yes |
OS, osteosarcoma; Dox, doxorubicin; CIS, cisplatin; MTX, methotrexate; ETO, etoposide; IFO, ifosfamide; CH, chemotherapy.