Table 3. Pharmacokinetic profiles of Gem and Gem-TSLnps in mouse.

Parameter	Gem	Gem-TSLnps	p-value
Vd (mL)	93.64 ± 1.79	24.26 ± 0.71	***
CL (mL/hr)	239.06 ± 0.02	14.21 ± 0.77	***
t1/2(hr)	0.27 ± 0.01	1.20 ± 0.03	**
K12 (1/hr)	0.45 ± 0.02	0.01 ± 0.003	***
K21 (1/hr)	2.85 ± 0.05	0.59 ± 0.12	***
K10 (1/hr)	2.55 ± 0.06	0.59 ± 0.02	***
AUC (μghr/mL)	2.09 ± 0.01	35.17 ± 0.04	***
AUMC (μghr2/mL)	0.82 ± 0.02	60.01 ± 1.59	***
MRT (hr)	0.39 ± 0.02	1.71 ± 0.05	***

Intraperitoneal injection of free Gem 20 mg/kg, Gem-TSLnps (dose equivalent Gem 10 mg/kg)

**< 0.01

***< 0.001

ns = not significant (mean ± SD).