Table 1.

Changes in ocular surface parameters over time

Parameters	Pretreatment	1 month		2 months		3 months
			p-value		p-value		p-value
Telangiectasia
%	92.3 (60.9–98.9)	87.7 (59.5–97.2)	0.604	69.2 (40.9–88.0)	0.078	61.5 (34.4–83.0)	0.041
Number/eye	7.3 (5.2–9.4)	5.2 (3.1–7.3)	0.015	3.4 (1.3–5.5)	<0.001	2.8 (0.8–4.9)	<0.001
Anterior shift of MCJ, %	53.8 (28.2–77.6)	40.8 (19.0–66.9)	0.143	38.5 (17.0–65.6)	0.130	38.5 (17.0–65.6)	0.130
Lid margin irregularity, %	38.5 (17.0–65.6)	39.2 (17.4–66.3)	0.387	23.1 (7.6–52.2)	0.133	30.8 (12.0–59.1)	0.300
Gland orifice plugging
%	100.0	75.0		69.2		69.2
Number/eye	6.3 (4.5–8.1)	3.4 (1.5–5.2)	<0.001	2.2 (0.4–4.0)	<0.001	1.8 (0.0–3.6)	<0.001
Meibum score	2.3 (1.9–2.7)	2.2 (1.8–2.6)	0.617	2.2 (1.8–2.6)	0.658	1.8 (1.5–2.2)	0.011
Meiboscore
Upper eyelid	1.4 (0.8–2.0)	1.2 (0.6–1.8)	0.269	1.3 (0.7–1.9)	0.589	1.2 (0.6–1.8)	0.283
Lower eyelid	1.2 (0.8–1.7)	1.2 (0.8–1.7)	0.921	1.0 (0.5–1.5)	0.082	1.0 (0.5–1.5)	0.082
Total score	2.6 (1.7–3.6)	2.5 (1.5–3.4)	0.418	2.3 (1.3–3.3)	0.091	2.2 (1.3–3.2)	0.036
Schirmer I test result, mm	7.5 (6.4–8.7)	8.6 (7.4–9.9)	0.177	7.9 (6.7–9.2)	0.614	10.1 (8.9–11.3)	0.002
Tear breakup time, seconds	3.3 (1.6–5.0)	6.2 (4.5–7.9)	0.0007	6.4 (4.7–8.0)	0.0003	7.5 (5.9–9.2)	<0.0001
Fluorescein staining score	1.5 (0.9–2.2)	0.5 (0–1.2)	0.0004	0.4 (0–1.0)	<0.0001	0.4 (0–1.0)	<0.0001

Notes: Percentages for telangiectasia, shift of MCJ, lid margin irregularity, and plugging are percentages of eyes in which each sign is present. Data are presented as mean (95% CI). As the plugged ratio was 100% before treatment, CIs could not be estimated. p-values show comparisons with pretreatment values.

Abbreviation: MCJ, mucocutaneous junction.