Table 2.

Tear lipid layer thickness immediately before and 20 minutes after administration of topical diquafosol sodium in eyes with dry eye disease and meibomian gland dysfunction

Parameters			Compared with pretreatment	Compared with first measurement
		LLT value (nm)	p-value	p-value
First measurement (before diquafosol administration)	Pretreatment	81.8 (64.5–99.2)
	1 month	77.0 (59.3–94.7)	0.563
	2 months	81.1 (63.7–98.4)	0.925
	3 months	79.7 (62.3–97.1)	0.791
Second measurement (20 minutes after diquafosol administration)	Pretreatment	94 (76.6–111.4)		0.138
	1 month	88.5 (70.8–106.2)	0.511	0.177
	2 months	90.5 (73.2–107.9)	0.671	0.247
	3 months	96.7 (79.3–114.1)	0.741	0.039

Note: 95% CIs are shown in parentheses.

Abbreviation: LLT, lipid layer thickness.