Figure 6.

The Endothelial Monolayer Permeability Is Increased in the Aorta of mgR/mgR Mice

Detection of ATTO 590-labeled fluorescent decoy penetration, apparent as bright red fluorescence, into aortic wall of WT (A, n = 1) and mgR/mgR mice (B, n = 1). ZO-1 and occludin stain (red) is reduced in mgR/mgR mice (n = 3) in comparison to WT animals (n = 2) (C). The decrease is visible because of lower false orange fluorescence color intensity in mgR/mgR mice aortic tissue staining after merging the endothelial cell marker CD31 (green) and tight junction protein stainings (red).