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. Author manuscript; available in PMC: 2018 Sep 21.
Published in final edited form as: Chem Commun (Camb). 2017 Sep 21;53(76):10508–10511. doi: 10.1039/c7cc05722a

Figure 2.

Figure 2

Environments in MS2 protein complexes of RNA phosphates for which PS2 modification results in significant gains of affinity. (A) P14. (B) P5. (C) P12. PS2 phosphorus atoms are highlighted as filled circles in yellow along with selected side chains. Rose- and cyan-colored spheres indicate the pro-Rp and -Sp sulfurs, respectively, and the calculated position of the 2´-OMe carbon (panel A) is green. Distances in Å are based on a P-S distance of 1.9 Å. (D) P15-17 are directed away from the protein. The panel depicts hairpins in two different orientations (gray and pink carbon atoms) bound to an MS2 dimer (right-hand border) positioned on a crystallographic dyad.