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. 2017 Mar 21;23(4):1001–1013. doi: 10.1038/mp.2017.15

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Maternal immune activation (MIA) effects on translation and transcriptional mechanisms. This figure shows results supporting the idea that MIA dysregulates processes involved in translation and transcription. Panel a shows process level enrichments for MIA-upregulated genes. Panel b shows enrichment odds ratios for MIA-downregulated or -upregulated gene sets with downstream FMRP and CHD8 targets (the * indicates enrichment test passing false discovery rate (FDR) q<0.05 threshold). Panels c and d show enrichment between upregulated genes in MIA and autism spectrum disorder (ASD) cortical transcriptome datasets (panel c for the Voineagu dataset and panel d for the Gupta dataset). Panels e and f show process level enrichments for the common upregulated genes between MIA and ASD (panel e for the Voineagu dataset and panel f for the Gupta dataset).