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. 2017 Sep 21;8:637. doi: 10.1038/s41467-017-00576-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — In vivo expression of DMAb-αPcrV and DMAb-BiSPA in mice. a B6.Cg-Foxn1 < nu > /J mice (n = 5/group) were administered 100 µg of DMAb-αPcrV by IM-EP. Serum levels of human IgG were monitored over 120 days. b Day 7 serum levels in BALB/c mice (n = 10/group) administered 100 and 300 µg for DMAb-αPcrV. The line represents the mean value. c Day 7 serum binding to PcrV protein in BALB/c mice (n = 10/group) administered 100 µg of DMAb-αPcrV. d B6.Cg-Foxn1 < nu > /J mice (n = 5/group) were administered 100 µg of DMAb-BiSPA by IM-EP. Serum levels of human IgG were monitored over 120 days. e, b Day 7 serum levels in BALB/c mice (n = 10/group) administered 100 and 300 µg for DMAb-BiSPA. The line represents the mean value. f Day 7 serum binding to PcrV protein in BALB/c mice (n = 10/group) administered 100 µg of DMAb-BiSPA