Fig. 6.

Histology of acute pneumonia at 48 h post infection with P. aeruginosa. a Post-EP with DMAb-DVSF3 showing coalescing areas of marked alveolar infiltrate and hemorrhage (10 × magnification). b Alveoli have marked neutrophilic infiltrates, hemorrhage, and areas of necrosis (inset). c Mild pneumonia and occasional bronchiolar debris with DMAb-αPcrV (10 × magnification). d Alveolar infiltrates comprises mixed neutrophilic and macrophage populations (inset). e DMAb-BiSPA group with mild alveolitis (10 × magnification). f Primarily neutrophilic infiltrates and mild hemorrhage in alveolar spaces (inset). g MEDI3902 IgG control demonstrates moderate alveolitis (10 × magnification). h Alveolar spaces contain neutrophils admixed with cellular debris and hemorrhage (inset). Representative data from five mice/group