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. 2017 Sep 21;7:12064. doi: 10.1038/s41598-017-10924-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of cannabidiol on ethanol-induced liver oxidative/nitrative stress. (A,B) Representative sections from each group with MDA and NT staining (markers of lipid peroxidation and protein nitration, respectively) at 200X magnification. Brown depicts increases of MDA and NT staining intensities in EtOH-fed groups. Panels (C) and (D) present quantification of HNE and NT ELISA respectively. Values represent means ± SEM (n = 5–7). *P < 0.05 vs. Pair-fed group, ^# P < 0.05 vs. EtOH group determined by One-way ANOVA, followed by Tukey’s post-hoc test.