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. 2017 Sep 21;7:12078. doi: 10.1038/s41598-017-12171-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treg-cell intrinsic deletion of Blimp1 leads to mild intestinal inflammation. (A) Left: scatter plots showing histology score of cecum (CE), colon (CO) and rectum (RE) among control (Ctrl), CD4^creCKO and Foxp3^creCKO mice. Each symbol represents one mouse (N ≥ 5 mice/group, Bars indicate average ± SEM. *P < 0.05, **P < 0.01, one-way ANOVA. Right: representative pictures (20X magnification) of histological sections of colon of mice in each group. (B) Representative FACS plots (left) and scatter plots (right) showing the frequency of IL17A expression in TCRβ⁺ CD4⁺ Foxp3⁻ cells in spleen (SP) and large intestine lamina propria (LI-LP) from Ctrl, CD4^creCKO or Foxp3^creCKO mice after stimulation. Right scatter plots: Each symbol represents one mouse (N ≥ 4 mice/group). Bars indicate average ± SEM. **P < 0.01, one-way ANOVA. (C) Representative FACS plots (left) and Scatter plots showing the frequency (right, top) or the total numbers (right, bottom) of IL10-producing cells in TCRβ⁺ CD4⁺ Foxp3⁻ or TCRβ⁺ CD4⁺ Foxp3⁺ cells in the SP from Ctrl, CD4^creCKO or Foxp3^creCKO mice. Each symbol represents one mouse (N ≤ 6 mice/group). Bars indicate average ± SEM. *P < 0.05, **P < 0.01, one-way ANOVA.