Table 1.
Variables Comparisons between Subjects with and without Cerebral Microbleeds.
| Overall | Deep/infratentorial CMBs | Strictly lobar CMBs | |||||||
|---|---|---|---|---|---|---|---|---|---|
| +(n = 134) | −(n = 828) | p | +(n = 85) | −(n = 877) | p | +(n = 49) | −(n = 913) | p | |
| Age, years, mean (SD) | 66.41 (9.66) | 61.81 (8.18) | <0.001 | 66.89 (10.02) | 62.03 (8.23) | <0.001 | 65.32 (8.62) | 62.31 (8.53) | 0.015 |
| Sex, men, n (%) | 61 (44.9) | 364 (44.1) | 0.926 | 40 (47.1) | 385 (43.9) | 0.648 | 20 (40.8) | 405 (44.4) | 0.660 |
| Age and sex-adjusted | |||||||||
| Hypertension, n (%) | 63 (46.3) | 294 (35.6) | 0.270 | 46 (54.1) | 311 (35.5) | 0.021 | 16 (32.7) | 341 (37.3) | 0.216 |
| DM, n (%) | 21 (15.4) | 108 (13.1) | 0.891 | 13 (15.3) | 116 (13.2) | 0.828 | 8 (16.3) | 121 (13.3) | 0.810 |
| Hyperlipidemia, n (%) | 14 (10.3) | 44 (5.3) | 0.111 | 11 (12.9) | 47 (5.4) | 0.032 | 2 (4.1) | 56 (6.1) | 0.423 |
| Cigarette Smoking, n (%) | 31 (22.8) | 219 (26.5) | 0.207 | 22 (25.8) | 228 (26.0) | 0.768 | 9 (18.3) | 241 (26.4) | 0.156 |
| Obesity, n (%) | 10 (7.4) | 43 (5.2) | 0.226 | 9 (10.6) | 44 (5.0) | 0.019 | 1 (2.0) | 52 (5.7) | 0.303 |
| Coronary artery disease, n (%) | 13 (9.6) | 37 (4.5) | 0.020 | 11 (12.9) | 39 (4.4) | 0.003 | 2 (4.1) | 48 (5.3) | 1.000 |
| Chronic kidney disease, n (%) | 2 (1.5) | 12 (1.5) | 0.572 | 2 (2.4) | 12 (1.4) | 0.914 | 0 | 14 (1.5) | 0.999 |
| Systolic BP*, mmHg, mean (SD) | 131.4 (18.3) | 127.8 (12.6) | 0.224 | 132.4 (16.9) | 127.9 (16.5) | 0.206 | 129.0 (20.6) | 128.3 (16.4) | 0.993 |
| Diastolic BP*, mmHg, mean (SD) | 79.7 (12.1) | 78.6 (12.7) | 0.816 | 81.1 (12.1) | 78.5 (12.6) | 0.294 | 76.7 (10.9) | 78.9 (10.9) | 0.222 |
| Pulse pressure*, mmHg, mean (SD) | 51.8 (12.1) | 49.2 (10.3) | 0.137 | 51.3 (11.5) | 49.4 (10.5) | 0.547 | 52.3 (13.5) | 49.3 (10.4) | 0.153 |
| LDL†, mg/dl, mean (SD) | 112.9 (28.0) | 117.8 (31.6) | 0.506 | 114.1 (28.7) | 117.4 (31.4) | 0.893 | 109.9 (26.6) | 117.5 (31.4) | 0.149 |
| TG†, mg/dl, mean (SD) | 128.3 (98.9) | 119.6 (73.7) | 0.125 | 136.2 (116.2) | 119.3 (72.9) | 0.037 | 114.1 (59.4) | 121.2 (78.6) | 0.655 |
| HDL†, mg/dl, mean (SD) | 54.9 (12.7) | 56.1 (14.4) | 0.647 | 53.6 (12.1) | 56.1 (14.4) | 0.239 | 57.1 (13.8) | 55.8 (14.2) | 0.508 |
| Lacune >1, n (%) | 26 (19.1) | 19 (2.3) | <0.001 | 24 (28.2) | 21 (2.4) | <0.001 | 2 (4.1) | 43 (4.7) | 0.583 |
| Moderate to severe WMH, n (%) | 65 (47.8) | 86 (10.4) | <0.001 | 49 (57.6) | 102 (11.6) | <0.001 | 16 (32.7) | 135 (14.8) | 0.018 |
| Carotid intima-media thickness | |||||||||
| Mean value, mm, mean (SD) | 0.73 (0.13) | 0.68 (0.12) | 0.097 | 0.74 (0.14) | 0.68 (0.12) | 0.049 | 0.71 (0.12) | 0.69 (0.13) | 0.825 |
| Top quartile, n (%) | 58 (43.0) | 211 (26.0) | 0.034 | 43 (51.2) | 226 (26.2) | 0.002 | 15 (30.6) | 254 (28.3) | 0.711 |
| Antiplatelets, n (%) | 8 (5.9) | 30 (3.6) | 0.733 | 5 (5.9) | 33 (3.8) | 0.856 | 3 (6.1) | 35 (3.8) | 0.685 |
*p value was further adjusted for antihypertensive medicines using. † p value was further adjusted for statins using.