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. 2017 Sep 21;7:12050. doi: 10.1038/s41598-017-11416-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The MetS-VLDL induced O-GlcNAcylation of Cx40 and Cx43. (a) The immunoblot shows increase in total O-GlcNAcylated Cx40 and Cx40 proteins in MetS-VLDL group. (b) Densitometry demonstrates that in the MetS-VLDL group, a significant increase in O-GlcNAcylation levels for both Cx40 and Cx43 (n = 4 for each group; 1.37 ± 0.26 folds to control, ^$P = 0.03 for Cx40 and 1.36 ± 0.15 folds to control, ^$P = 0.02 for Cx43).