Fig. 3.

Comparison of CUG-BP2 RRM3/5′-UUUAA-3′ and CUG-BP1 RRM3/5′-UGUGUG-3′ complexes. The CUG-BP2 RRM3/5′-UUUAA-3′ complex is represented with green protein side-chains and the RNA in yellow and the CUG-BP1 RRM3/5′-UGUGUG-3′ complex with purple protein side-chains and the RNA in cyan. a Schematic representation of the arrangement of the nucleotides of 5′-UUUAA-3′ and 5′-UGUGUG-3′ RNAs in the binding pockets. b Detailed view of protein-RNA interactions in each binding pocket comparing CUG-BP2 RRM3 bound to 5′-UUUAA-3′ on the left and CUG-BP1 RRM3 bound to 5′-UGUGUG-3′ on the right. c, d Overlays of the complexes with protein backbone shown in ribbon and aromatic protein side-chains and the RNAs represented as sticks. For clarity, the bonds to OP1, OP2 and O4’ are removed. (c) shows the RNA and (d) shows the aromatic side-chains