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. 2017 Sep 21;8:654. doi: 10.1038/s41467-017-00631-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Translation inhibition of COX-2 mRNA by CUG-BP2. a CUG-BP2 constructs. The flag-tag is depicted as a green bar and the RRMs as rounded rectangles. b Luciferase reporter gene. The coding sequence of the renilla luciferase is fused to the first sixty nucleotides of COX-2 mRNA 3′-UTR. c Luciferase reporter assay. Upper panel: normalized renilla/firefly luciferase activities for the different CUG-BP2 constructs. All the values are normalized to the negative control, which is the empty vector. Statistical significance was tested using the student test (a: significantly different from WT, p < 0.05; b: significantly different from control, p < 0.05). Error bars represent s.d. Lower panel: western blot