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. 2017 Apr 1;91(10):3385–3402. doi: 10.1007/s00204-017-1966-1

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 8 — Requirement for continued JAK-STAT signaling to NCC migration impairment. a NCC were allowed to migrate for 48 h. During this time, they were exposed to IFNβ while ruxolitinib (10 µM) was added to the culture medium at different time points after the start of the migration. The percentage of migrated cells was quantified for all conditions after 48 h. Migration was inhibited ≥25% in all conditions denoted in blue. Ruxolitinib without IFNβ had no effect on migration. b Graphical representation of the effects of IFNβ and JAK-STAT pathway-inhibitors on the transcription of target genes and on the functionality of NCC. NCC migration was unimpaired in the absence of IFNβ or when IFNβ was present together with ruxolitinib. NCC migration was impaired when IFNβ was present alone, or when ruxolitinib was added ≥10 h after IFNβ. (Color figure online)