TABLE 3.

Cyp51 substitutions in non-A. fumigatus organisms and their correspondence to the reference positions used in the text

Organism	Reference positiona		Reference	Observed substitution		Reference
	Gene	Positionb		Gene	Substitution
A. flavus	Afcyp51A	Y68	29	cyp51A	Y132N	160
	Afcyp51A	K133	29	cyp51A	K197N	160
	Afcyp51A	NA		cyp51A	A205T	149
	Afcyp51A	D280	29	cyp51A	D282E	160
	Afcyp51A	M286	29	cyp51A	M288L	160
	Afcyp51A	T470	29	cyp51A	T469S	160
	Ztcyp51B	H430	29	cyp51B	H399P	160
	Ztcyp51B	A453	29	cyp51B	D411N	160
	Ztcyp51B	T496	29	cyp51B	T454P	160
	Ztcyp51B	NA		cyp51B	T486P	160
	Afcyp51C	M54	Proposed here	cyp51C	M54T	149
	Afcyp51C	S196	Proposed here	cyp51C	S196F	161
	Afcyp51C	S240	Proposed here	cyp51C	S240A	149, 162
	Afcyp51C	D254	Proposed here	cyp51C	D254N	149
	Afcyp51C	I285	Proposed here	cyp51C	I285V	149
	Afcyp51C	Y319	Proposed here	cyp51C	Y319H	149, 191
	Afcyp51C	A324	Proposed here	cyp51C	A324P	161
	Afcyp51C	N423	Proposed here	cyp51C	N423D	161
	Afcyp51C	V465	Proposed here	cyp51C	V465 M	161
A. terreus	Afcyp51A	M220	29	cyp51A	M217I	165
A. niger	Afcyp51A	K230	29	cyp51A	R228Q	166
A. tubingensis	Afcyp51A	L21	29	cyp51A	L21F	166

^aAccession numbers for reference sequences are as follows: A. fumigatus cyp51A, AF338659; Zymoseptoria tritici (anamorph of Mycosphaerella graminicola) cyp51B, AY253234; and cyp51C, AKQ20794.1.

^bNA, not applicable (the respective residue was not found at this position in publicly deposited A. flavus sequences).