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. 2017 Aug 30;30(4):991–1014. doi: 10.1128/CMR.00046-17

TABLE 1.

Roles for BAFF system molecules in immunizationa

Molecule Role(s) Method(s) of proof Reference(s)
BAFF Mediating antibody response to TD and TI antigens Immunization of BAFF−/− mice with TD and TI antigens 6, 9, 68, 69
Augmenting antibody responses against vaccines as an adjuvant Immunization of exptl animals with BAFF-containing vaccines 7, 9094
APRIL Inducing IgA isotype switch and production in response to TD and TI-I antigens Systemic and mucosal immunization of normal, APRIL−/−, and APRIL-transgenic mice with TD and TI antigens 19, 71, 72
Augmenting antibody responses against vaccines as an adjuvant Immunization of exptl animals with APRIL-containing vaccines 91, 92
Immunization of APRIL Tg mice with TD and TI-II antigens 20
BAFF-R Mediating antibody response to TD and TI antigens Immunization of BAFF-R−/− mice with TD and TI antigens 6, 9, 68, 69
TACI Mediating antibody response to TI-II antigens Immunization of TACI−/− mice with TI-II antigens or CVID patients with polysaccharide vaccines
TACI expression levels determine antibody responses to TI-II antigens Responses of newborn mice and XID mice to TI-II antigens 35, 50, 52, 7375, 79, 80
Mediating TD antigen-specific plasma cell survival Immunization of TACI−/− mice with TD antigens 85, 89
Controlling expansion of Tfh and GC cells Immunization of HIV-infected patients with influenza vaccine
BCMA Contributing to long-term survival of antigen-specific bone marrow plasma cells Immunization of BCMA−/− mice with a TD antigen 31
a

TD, T cell dependent; TI, T cell independent; TI-II, TI type II; APRIL Tg, APRIL transgenic; CVID, combined variable immunodeficiency; XID, X-linked immunodeficient; Tfh, T follicular helper; GC, germinal center; HIV, human immunodeficiency virus.