TABLE 1.

Roles for BAFF system molecules in immunization^a

Molecule	Role(s)	Method(s) of proof	Reference(s)
BAFF	Mediating antibody response to TD and TI antigens	Immunization of BAFF−/− mice with TD and TI antigens	6, 9, 68, 69
	Augmenting antibody responses against vaccines as an adjuvant	Immunization of exptl animals with BAFF-containing vaccines	7, 90–94
APRIL	Inducing IgA isotype switch and production in response to TD and TI-I antigens	Systemic and mucosal immunization of normal, APRIL−/−, and APRIL-transgenic mice with TD and TI antigens	19, 71, 72
	Augmenting antibody responses against vaccines as an adjuvant	Immunization of exptl animals with APRIL-containing vaccines	91, 92
		Immunization of APRIL Tg mice with TD and TI-II antigens	20
BAFF-R	Mediating antibody response to TD and TI antigens	Immunization of BAFF-R−/− mice with TD and TI antigens	6, 9, 68, 69
TACI	Mediating antibody response to TI-II antigens	Immunization of TACI−/− mice with TI-II antigens or CVID patients with polysaccharide vaccines
	TACI expression levels determine antibody responses to TI-II antigens	Responses of newborn mice and XID mice to TI-II antigens	35, 50, 52, 73–75, 79, 80
	Mediating TD antigen-specific plasma cell survival	Immunization of TACI−/− mice with TD antigens	85, 89
	Controlling expansion of Tfh and GC cells	Immunization of HIV-infected patients with influenza vaccine
BCMA	Contributing to long-term survival of antigen-specific bone marrow plasma cells	Immunization of BCMA−/− mice with a TD antigen	31

^aTD, T cell dependent; TI, T cell independent; TI-II, TI type II; APRIL Tg, APRIL transgenic; CVID, combined variable immunodeficiency; XID, X-linked immunodeficient; Tfh, T follicular helper; GC, germinal center; HIV, human immunodeficiency virus.