Table 5.

Comparison of the ROC curves, IDI and NRI of the modified bleeding risk scores (by addition of labile INR defined as time in therapeutic range <65%).

	C-index	95% CI	z statistic*	p	IDI	p	NRI	p
vs. ATRIA
ATRIA + TTR <65%	0.751	0.727–0.774	7.514	<0.001	0.0326	<0.001	0.1527	<0.001
vs. ORBIT
ORBIT + TTR <65%	0.733	0.709–0.757	5.087	<0.001	0.0270	<0.001	0.1097	<0.001
vs. HEMORR2HAGES
HEMORR2HAGES + TTR <65%	0.729	0.704–0.752	4.689	<0.001	0.0159	<0.001	0.0598	0.007

CI = confidence interval; IDI = integrated discriminatory improvement; NRI = net reclassification index; TTR = time in therapeutic range. *For c-index comparison.