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. 2017 Aug 28;6(8):e373. doi: 10.1038/oncsis.2017.72

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Copyright © 2017 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The UPR intervention in chemotherapy resistance. UPR activation contributes to chemotherapy drug resistance by increasing drug detoxification and efflux pump expression, by modulating drug targets and activating antiapoptotic and prosurvival genes expression. Examples of anticancer drugs used several cancer types described in the literature are indicated.