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. 2017 Aug 28;6(8):e374. doi: 10.1038/oncsis.2017.73

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Copyright © 2017 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Growth pattern of WT and Tg(K6b-E6/E7) cervix during the estrous cycle. Ki67 determination (a) and 2-h BrdU incorporation (b) during the growth phases in transformation zone, and inner and outer cervix showed that oncogenes added suprabasal proliferating cells to those regularly present in the basal layer. Note the basal to suprabasal K5 distribution gradient, particularly evident in the outer cervix. Some basal (b), parabasal (p) and suprabasal (s) cells are indicated. (c) A histological comparison between WT and Tg(K6b-E6/E7) cervix of 9-week-old mice showed similar tissue appearance at each estrous cycle phase but a thicker epithelium during the growing phases in the latter than in the former, in some cases evidenced as epithelia invading the stroma (arrows). Scale bar, 100 μm.