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. 2017 Sep 21;7:12128. doi: 10.1038/s41598-017-12474-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Deoxyribonculease 1 reduces lung macrophages and areas of proteolysis. Cigarette smoke increases numbers of macrophages and neutrophils and the area of the lung with proteolysis in a murine model in vivo. The addition of DNase 1 reduces macrophage numbers and lung proteolysis. (A) Number of macrophages in the lung (n = 10). (B) Number of neutrophils in the lung (n = 10). The area of lung demonstrating area of proteolytic change was assessed using in situ zymography. (C) Shows staining for chromatin (blue) and staining for proteolysis (green). (D) Area of lung with proteolysis (n = 10).