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. 2017 Sep 21;7:12088. doi: 10.1038/s41598-017-12205-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of ticagrelor on platelet aggregation and infarct volume 22 hours after reperfusion. (A) Experimental protocol for the measurement of platelet aggregation and infarct volume. (B) Adenosine diphosphate-induced platelet aggregation after administration of ticagrelor. Data are expressed as means ± standard errors of the mean (SEMs). N = 3 or 4 per group; **P < 0.01 vs. vehicle; Student’s t-test. (C) Representative images of triphenyltetrazolium chloride-stained coronal slices 22 hours after reperfusion. (D) Quantitative measurements of infarct volume 22 hours after reperfusion. Data are expressed as means ± SEMs. N = 10 to 12 per group; *P < 0.05 vs. vehicle; Student’s t-test.