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. 2017 Sep 21;7:12088. doi: 10.1038/s41598-017-12205-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vitro analysis using oxygen-glucose deprivation (OGD) stress in human brain microvessel endothelial cells (HBMVECs). (A) The experimental protocol used to assess the effects of ticagrelor against OGD stress in HBMVECs. (B) Cell viability measured using cell counting kit 8 two hours after reoxygenation. Data are expressed as means ± standard errors of the mean (SEMs). N = 12 per group; ^#P < 0.05 vs. vehicle; Dunnett’s test. The effects of ticagrelor on the phosphorylation of endothelial nitric oxide synthase (C) and extracellular signal-regulated kinase 1/2 (D) 2 hours after reoxygenation. Data are expressed as means ± SEMs. n = 4 per group; ^##P < 0.01 vs. vehicle; Dunnett’s test. The cropped blots are used in this Figure and the full-length blots are presented in Supplementary Figure S4.