Table 3.
Differentially methylated positions for WC and abdominal obesity (WC ≥ 88 cm for women and ≥ 102 cm for men)
| WC | Abdominal obesity | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CpG site | CHR | Position | Nearest genea | Featureb | Delta β valuec |
p valued | FDRd | Delta β valuec |
p valued | FDRd |
| cg07839457 | 16 | 57023022 | NLRC5 | TSS1500 | 0.0030 | 2.24E − 10 | 9.61E − 05 | 0.0340 | 6.86E − 05 | 8.17E − 01 |
| cg00574958 | 11 | 68607622 | CPT1A | 5′ UTR | − 0.0007 | 1.00E − 08 | 1.55E − 03 | − 0.0135 | 1.52E − 08 | 6.54E − 03 |
| cg25954539 | 6 | 31323677 | HLA-B | Body | 0.0022 | 1.08E − 08 | 1.55E − 03 | 0.0316 | 5.78E − 05 | 7.75E − 01 |
| cg08818207 | 6 | 32820355 | TAP1 | Body | 0.0020 | 3.46E − 08 | 3.71E − 03 | 0.0303 | 5.14E − 05 | 7.75E − 01 |
| cg04927537 | 17 | 76976091 | LGALS3BP | TSS200 | 0.0013 | 6.19E − 08 | 5.08E − 03 | 0.0195 | 4.23E − 05 | 7.75E − 01 |
| cg22107533 | 15 | 45028083 | TRIM69 | TSS1500 | 0.0015 | 7.76E − 08 | 5.08E − 03 | 0.0252 | 2.14E − 04 | 8.17E − 01 |
| cg01309328 | 6 | 32811253 | PSMB8 | Body | 0.0014 | 8.69E − 08 | 5.08E − 03 | 0.0202 | 6.26E − 06 | 6.45E − 01 |
| cg23533285 | 6 | 31322348 | HLA-B | Body | 0.0015 | 9.47E − 08 | 5.08E − 03 | 0.0241 | 2.99E − 04 | 8.17E − 01 |
| cg23570810 | 11 | 315102 | IFITM1 | Body | 0.0018 | 1.12E − 07 | 5.35E − 03 | 0.0182 | 1.12E − 05 | 6.68E − 01 |
| cg00218406 | 6 | 31431407 | HCP5 | 3′ UTR | 0.0022 | 1.66E − 07 | 7.12E − 03 | 0.0335 | 7.64E − 04 | 8.17E − 01 |
| cg08099136 | 6 | 32811251 | PSMB8 | Body | 0.0015 | 1.93E − 07 | 7.53E − 03 | 0.0180 | 3.23E − 04 | 8.17E − 01 |
| cg11202345 | 17 | 76976057 | LGALS3BP | 1stExon | 0.0011 | 2.15E − 07 | 7.70E − 03 | 0.0203 | 4.65E − 05 | 7.75E − 01 |
| cg25178683 | 17 | 76976267 | LGALS3BP | TSS1500 | 0.0011 | 3.50E − 07 | 1.16E − 02 | 0.0136 | 1.41E − 05 | 6.68E − 01 |
| cg01971407 | 11 | 313624 | IFITM1 | TSS1500 | 0.0010 | 4.69E − 07 | 1.44E − 02 | 0.0079 | 5.71E − 05 | 7.75E − 01 |
| cg25843003 | 6 | 31431312 | HCP5 | 3′ UTR | 0.0009 | 7.03E − 07 | 2.01E − 02 | 0.0142 | 8.12E − 05 | 8.17E − 01 |
| cg22940798 | 6 | 32805554 | TAP2 | Body | 0.0010 | 1.03E − 06 | 2.75E − 02 | 0.0187 | 5.19E − 04 | 8.17E − 01 |
| cg20399616 | 12 | 25055967 | BCAT1 | Body | − 0.0012 | 1.20E − 06 | 2.97E − 02 | − 0.0145 | 9.27E − 04 | 8.17E − 01 |
| cg05439368 | 15 | 45028098 | TRIM69 | TSS1500 | 0.0015 | 1.25E − 06 | 2.97E − 02 | 0.0263 | 1.99E − 04 | 8.17E − 01 |
| cg06538684 | 12 | 12511223 | LOH12CR2 | TSS1500 | 0.0011 | 1.62E − 06 | 3.53E − 02 | 0.0173 | 9.31E − 05 | 8.17E − 01 |
| cg23235965 | 6 | 30459540 | HLA-E | Body | 0.0011 | 1.64E − 06 | 3.53E − 02 | 0.0238 | 5.37E − 05 | 7.75E − 01 |
| cg13558971 | 1 | 203597085 | ATP2B4 | 5′ UTR | − 0.0007 | 1.78E − 06 | 3.64E − 02 | − 0.0092 | 1.82E − 03 | 8.17E − 01 |
| cg13348877 | 18 | 78005237 | PARD6G | 1stExon | − 0.0002 | 2.01E − 06 | 3.93E − 02 | − 0.0021 | 8.15E − 05 | 8.17E − 01 |
| cg08996521 | 3 | 50649994 | CISH | TSS1500 | 0.0005 | 2.52E − 06 | 4.70E − 02 | 0.0131 | 1.10E − 04 | 8.17E − 01 |
aCpGs are located in the gene if no distance is indicated
bBased on manifest feature annotation Illumina. IGR, intergenic region
cNegative beta values indicate lower DNA methylation (hypo-methylation) in cases compared with controls
d p values and FDR corresponding to M values. Table is sorted on WC associated p values. All significant hits for both outcomes are included