Table 6.
Replicated differentially methylated positions (DMPs) associated with WC and abdominal obesity reported by previous EWAS
| WC | Abdominal obesity | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CpG site | CHR | Position | Nearest gene (distance)a | Featureb | Beta differencec | p valued | FDRd | Beta differencec | p valued | FDRd |
| cg00574958 | 11 | 68607622 | CPT1A | 5′ UTR | − 0.0007 | 1.02E − 08 | 9.87E − 06 | −0.0135 | 1.55E − 08 | 1.49E − 05 |
| cg04927537 | 17 | 76976091 | LGALS3BP | TSS200 | 0.0013 | 6.74E − 08 | 3.26E − 05 | 0.0195 | 4.44E − 05 | 1.07E − 02 |
| cg25178683 | 17 | 76976267 | LGALS3BP | TSS1500 | 0.0011 | 3.96E − 07 | 1.28E − 04 | 0.0136 | 1.54E − 05 | 7.22E − 03 |
| cg07504977 | 10 | 102131012 | LINC00263 (− 2321) | IGR | 0.0010 | 1.60E − 05 | 3.87E − 03 | 0.0240 | 2.24E − 05 | 7.22E − 03 |
| cg18335991 | 15 | 74724562 | SEMA7A | Body | 0.0009 | 2.22E − 05 | 4.30E − 03 | 0.0147 | 3.75E − 04 | 7.24E − 02 |
| cg27243685 | 21 | 43642366 | ABCG1 | Body | 0.0004 | 7.58E − 05 | 1.22E − 02 | 0.0037 | 1.72E − 02 | 3.77E − 01 |
| cg10927968 | 11 | 1807333 | CTSD | IGR | 0.0007 | 9.42E − 05 | 1.30E − 02 | 0.0082 | 1.27E − 02 | 3.77E − 01 |
| cg06500161 | 21 | 43656587 | ABCG1 | Body | 0.0003 | 2.15E − 04 | 2.60E − 02 | 0.0033 | 3.47E − 03 | 2.76E − 01 |
| cg13123009 | 6 | 31681882 | LY6G6E | TSS200 | 0.0004 | 3.22E − 04 | 3.46E − 02 | 0.0074 | 3.65E − 03 | 2.76E − 01 |
| cg17439800 | 1 | 208056493 | CD34 | IGR | 0.0006 | 5.09E − 04 | 4.92E − 02 | 0.0205 | 5.83E − 04 | 9.39E − 02 |
aCpGs are located in the gene if no distance is indicated. Distance is expressed in kilobase
bBased on manifest feature annotation Illumina. IGR, intergenic region
cNegative beta values indicate lower DNA methylation (hypo-methylation) in cases compared with controls
d p values and FDR corresponding to M values. Table is sorted on WC associated p values. All significant hits for both outcomes are included