Table 1.
Twenty most discriminating metabolites from orthogonal projections to latent structures discriminant analysis (sorted by absolute value of pcorr1 axis; variation related to variable magnitude)
| Cerebrospinal fluid | Plasma | Brain tissue | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Name | p1 | pcorr1 | Fold change | p Value (α = 5.21E-04)a | Name | p1 | pcorr1 | Fold change | p Value (α = 3.07E-04)a | Name | p1 | pcorr1 | Fold change | p Value (α = 2.06E-04)a |
| Tr | −0.91 | −0.95 | 0.64 | 1.68E-07 | Glutamine | 0.97 | 0.93 | 1.19 | 1.37E-03 | NaMN | 2.15 | 0.95 | 1.52 | 4.44E-03 |
| Citrate_isocitrate | −1.06 | −0.93 | 0.52 | 8.71E-08 | Proline | 1.39 | 0.91 | 1.43 | 1.74E-03 | CDP | 4.47 | 0.95 | 6.36 | 2.94E-02 |
| Carnitine | −0.78 | −0.9 | 0.76 | 2.90E-05 | Spermine | 1.38 | 0.9 | 1.45 | 6.81E-04 | ATP | 4.12 | 0.93 | 6.55 | 4.47E-02 |
| Myo-inositol | 0.77 | 0.86 | 1.38 | 1.29E-04 | Creatinine | 1.5 | 0.89 | 1.67 | 3.33E-06 | ADP | 3.24 | 0.92 | 2.53 | 7.97E-02 |
| Deoxyuridine | −0.6 | −0.82 | 0.83 | 2.66E-04 | DHA | −1.59 | −0.89 | 0.7 | 4.67E-03 | dGDP | 3.22 | 0.92 | 2.27 | 6.39E-02 |
| Cytosine | −0.61 | −0.8 | 0.79 | 6.89E-04 | Citrulline | 1.43 | 0.87 | 1.49 | 1.08E-02 | 3PG | 3.36 | 0.91 | 2.75 | 9.99E-02 |
| S-ArMet | 0.57 | 0.75 | 1.23 | 3.59E-03 | C12 | −1.75 | −0.84 | 0.6 | 8.70E-02 | Xanthine | −3.34 | −0.9 | 0.34 | 2.63E-02 |
| Creatinine | 0.5 | 0.75 | 1.12 | 1.40E-03 | C14:1OH | −1.58 | −0.82 | 0.71 | 6.03E-02 | UDP | 4.03 | 0.9 | 5.1 | 5.52E-02 |
| Ribose | 0.45 | 0.71 | 1.15 | 9.23E-04 | mHis_NmHis | −1.33 | −0.82 | 0.73 | 2.60E-03 | Hx | −3.38 | −0.9 | 0.34 | 2.22E-01 |
| mHis_NmHis | −0.63 | −0.7 | 0.68 | 8.27E-03 | NAcGlcnh2_NAcGalnh2_NAcManh2 | 1.23 | 0.82 | 1.42 | 2.80E-03 | IDP | 3.08 | 0.89 | 2.18 | 1.15E-01 |
| Allantoin | −0.6 | −0.69 | 0.82 | 2.91E-03 | Succ_mma | 1.44 | 0.81 | 1.32 | 1.24E-02 | Inosine | −3.49 | −0.89 | 0.28 | 1.98E-01 |
| hCar | 0.47 | 0.69 | 1.22 | 2.25E-02 | Arabitol_ribitol | 1.69 | 0.8 | 1.55 | 8.61E-02 | dimGly_nh2isobut | −2.52 | −0.88 | 0.51 | 1.84E-01 |
| Glucose | 0.46 | 0.68 | 1.2 | 2.19E-03 | Trigonelline | 1.85 | 0.79 | 1.58 | 4.00E-02 | Uracil | −2.9 | −0.88 | 0.47 | 2.44E-01 |
| Succ_mma | 0.36 | 0.66 | 1.08 | 4.89E-03 | C14 | −1.6 | −0.78 | 0.76 | 1.48E-01 | rib5P | −3.16 | −0.86 | 0.34 | 2.62E-01 |
| Aconitate | −0.54 | −0.64 | 0.78 | 1.42E-02 | oPro_pipec | 0.82 | 0.78 | 1.15 | 7.67E-03 | PCr | 4.38 | 0.86 | 4.81 | 2.69E-01 |
| Uridine | 0.45 | 0.63 | 1.19 | 4.74E-03 | C14 | −1.53 | −0.76 | 0.68 | 1.18E-01 | Niacin | −1.93 | −0.85 | 0.63 | 1.63E-01 |
| Valine | −0.4 | −0.59 | 0.83 | 4.95E-02 | C14:1 | −1.52 | −0.76 | 0.58 | 8.49E-02 | GuaBut | 2.35 | 0.85 | 1.88 | 2.59E-01 |
| Phenyl acetate | 0.8 | 0.59 | 2.05 | 3.72E-02 | C18:1 | −1.47 | −0.75 | 0.66 | 1.36E-01 | acMet | −2.78 | −0.85 | 0.54 | 3.10E-01 |
| Fructose | 0.4 | 0.59 | 1.2 | 1.69E-02 | C16 | −1.62 | −0.75 | 0.72 | 1.26E-01 | NADP | 3.67 | 0.84 | 2.27 | 1.94E-02 |
| C5 | −0.5 | −0.57 | 0.69 | 2.71E-02 | C16OH | −1.4 | −0.74 | 0.73 | 1.49E-01 | Tr | −2.3 | −0.84 | 0.6 | 2.04E-02 |
Abbreviations: 3PG Glycerate 3-phosphate, acMet N-acetylmethionine, C12 Dodecanoylcarnitine, C14 Tetradecanoylcarnitine, C14:1 Tetradecenoylcarnitine, C14:1OH Hydroxytetradecenoylcarnitine, C16 Hexadecanoylcarnitine, C16:1OH Hydroxyhexadecenoylcarnitine, C16OH Hydroxyhexadecanoylcarnitine, C18:1 Octadecenoylcarnitine, C5 Valerylcarnitine, CDP Cytidine 5′-diphosphate, dGDP Deoxyguanosine 5′-diphosphate, DHA Docosahexaenoic acid, dimGly_nh2isobut Dimethylglycine/2-aminoisobutyric acid, GuaBut Guanidinobutanoate, hCar Homocarnosine, Hx Hypoxanthine, IDP Inosine 5′-diphosphate, mHis_NmHis 3-Methylhistidine/N-methylhistidine, NAcGlcnh2_NAcGalnh2_NAcManh2 N-acetylglucosamine/N-acetylgalactosamine/N-acetylmannosamine, NADP Nicotinamide adenine dinucleotide phosphate, NaMN Nicotinamide mononucleotide, oPro_pipec 5-Oxoproline/ pipecolate, PCr Phosphocreatine, rib5P_xyl5P Ribose 5-phosphate/xylulose 5-phosphate, S-ArMet S-adenosylmethionine, Succ_mma Succinate/methylmalonate, Tr Thymidine, UDP Uridine 5′-diphosphate
p Values and fold changes for metabolites are shown
aCorrected α value (after Bonferroni correction)