Table 2.

Clinical cut-off values, sensitivity, and specificity of miRNAs

	Cut-off value	Sensitivity, % (95% CI)	Specificity, % (95% CI)	PPV, % (95% CI)	NPV, % (95% CI)	Likelihood ratio
miR-9	>4.035	67.3 (52.9–79.7)	80.0 (66.3–90.0)	77.8 (62.9–88.8)	70.2 (56.6–81.6)	3.4
miR-21	>1.975	82.7 (69.7–91.8)	72.0 (57.5–83.8)	75.4 (62.2–85.9)	80.0 (65.4–90.4)	3.0
miR-155	>3.880	65.4 (50.9–78.0)	96.0 (86.3–99.5)	94.3 (80.8–90.6)	71.6 (59.3–82.0)	15.9

95% CI 95% confidence interval, PPV positive predictive value, NPV negative predictive value