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. 2017 Jul 9;14(3):2101–2107. doi: 10.3892/etm.2017.4740

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Copyright: © Yao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — GC7 enhances gemcitabine sensitivity through inhibition of eIF5A2 in PDAC cells. (A) Western blot analysis for the expression of eIF5A2 in eIF5A2 siRNA-transfected cells. GAPDH was used as an internal control. (B-D) Cell Counting Kit-8 viability assay showing knockdown of eIF5A2 increasing gemcitabine sensitivity of pancreatic cancer cells. (E-G) Following knockdown of eIF5A2 using siRNA, Cell Counting Kit-8 cell viability assays were used to determine the sensitivity of gemcitabine or gemcitabine plus GC7 in pancreatic cancer cells treated with eIF5A2 siRNA.