Figure 4.

GC7 reverses gemcitabine-induced MDR1 in PDAC cells. (A) Western blot analysis was used to detect eIF5A2 expression in pancreatic cancer cells treated with gemcitabine, or gemcitabine in combination with GC7. Relative protein expression levels in PDAC cells were quantified by band density with GAPDH serving as a loading control. (B) Western blotting was used to detect eIF5A2 expression in pancreatic cancer cells treated with gemcitabine or gemcitabine in combination with siRNAs for eIF5A2. *P<0.05 vs. control; ^#P<0.05 vs. gemcitabine.