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. 2017 Sep 20;9:305. doi: 10.3389/fnagi.2017.00305

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Copyright © 2017 Dhamoon, Cheung, Bagci, Alperin, Sacco, Elkind and Wright.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Association of regional white matter hyperintensity volume asymmetry with baseline functional status. WMHV, white matter hyperintensity volume; Ant_PVM, anterior periventricular; Post_PVM, posterior periventricular. ^*Estimates in the table are in reference to right-sided WMHV: a positive estimate signifies lower baseline Barthel index scores with greater WMHV on the right compared to the left. Models are adjusted for: age, sex, diabetes, hypertension, coronary artery disease, physical activity, alcohol use, body mass index, marital status, insurance status, mini-mental state score, total white matter hyperintensity volume, and stroke and myocardial infarction occurring during follow-up. (B) Association of regional white matter hyperintensity volume asymmetry with additional annual functional decline. WMHV, white matter hyperintensity volume; Ant_PVM, anterior periventricular; Post_PVM, posterior periventricular. ^*Estimates in the table are in reference to right-sided WMHV: a positive estimate signifies additional annual decline in Barthel index scores with greater WMHV on the right compared to the left. Models are adjusted for: age, sex, diabetes, hypertension, coronary artery disease, physical activity, alcohol use, body mass index, marital status, insurance status, mini-mental state score, total white matter hyperintensity volume, and stroke and myocardial infarction occurring during follow-up.