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. 2017 Sep 20;8:1169. doi: 10.3389/fimmu.2017.01169

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Copyright © 2017 Young, Khiew, Yang, Vannier, Yin, Sciammas, Alegre and Chong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Delayed CTLA4-Ig prevented acute rejection in C57BL/6 WT and μMT recipients. (A) Experimental design. (B) WT or (C) μMT recipients were transplanted with BALB/c donor hearts and received no treatment (No Rx), or CTLA4-Ig given twice a week starting on D0 (CLTA4-Ig D0+) or on D6 (CLTA4-Ig D6+), or isotype Ig starting on D6, for up to 30 days. Graft survival was monitored for 30 days.