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. 2017 Sep 20;8:1169. doi: 10.3389/fimmu.2017.01169

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Copyright © 2017 Young, Khiew, Yang, Vannier, Yin, Sciammas, Alegre and Chong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of delayed CTLA4-Ig on the precursor frequency of IFNγ-producing T cells in fully allogeneic heart transplant recipients. BALB/c hearts were transplanted into C57BL/6 mice and were not treated (No Rx) or were treated with CLTA4-Ig on D6, 9, and 13 post-Tx (CTLA D6-14), and sacrificed on day 14 posttransplantation and restimulated ex vivo. (A) Sample flow plots of allospecific IFNγ staining of T cells from No Rx recipients. (B,C) Total number of allospecific IFNγ-producing CD4⁺ (C) or CD8⁺ (D) from the spleens of recipients receiving WT BALB/c hearts. Data shown from individual mice (N = 4–7/group) and as mean ± SEM. *p < 0.05, by one-way ANOVA. ^##p < 0.01 by two-tailed t-test.