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. 2017 Sep 20;8:1169. doi: 10.3389/fimmu.2017.01169

Figure 6.

Figure 6

Effect of delayed CTLA4-Ig on the precursor frequency of IFNγ-producing T cells in haplo-mismatched F1 heart transplant recipients. 2W-OVA.F1 (BALB/c X 2W-OVA.C57BL/6) hearts were transplanted into C57BL/6 mice as described for Figure 5. (A) Comparison of heart survival, (B,C) total number of allospecific IFNγ-producing CD4+ (B) or CD8+ (C) T cells from the spleens of recipients receiving F1 hearts. Data shown from individual mice (N = 3–8/group) as mean ± SEM. *p < 0.05, ***p < 0.001, ****p < 0.0001 by one-way ANOVA.