Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 20;8:1169. doi: 10.3389/fimmu.2017.01169

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Young, Khiew, Yang, Vannier, Yin, Sciammas, Alegre and Chong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

CTLA4-Ig treatment promotes long-term acceptance of second, donor-specific heart allografts in recipients that were successfully treated for acute rejection. C57BL/6 recipients of primary BALB/c heart transplant were treated with CTLA4-Ig 2×/week from day 6 posttransplantation. At 30 days post primary transplant, a second heart was transplanted into each recipient, and the survival of the secondary hearts was monitored. (A) Cartoon depicting the experimental protocol. (B) Graft survival curve for primary (N = 14) and secondary heart grafts (N = 5 and N = 8). Survival is determined from the time each allograft was transplanted. (C) Histological scoring of surviving heart grafts at sacrifice. (D) Sample histological slides from primary and secondary heart grafts (20×). Data shown from individual mice (N = 8–9) as mean ± SEM. *p < 0.05 by two-tailed t-test.