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. 2017 Jul 9;14(3):2255–2260. doi: 10.3892/etm.2017.4729

Figure 3.

Figure 3.

Hesperetin inhibits cardiac fibrosis in MI mice. (A) Increased collagen deposition was present in the Vehicle-MI group at 8 weeks after left anterior descending coronary artery ligation surgery, which was reduced by hesperetin treatment (Picrosirius red staining; magnification, ×40). mRNA levels of (B) CTGF, (C) collagen I and (D) collagen III in the hearts of mice following Sham or MI surgery with or without hesperetin treatment. The Vehicle-MI group displayed increased mRNA levels of CTGF as well as collagen I and III when compared to the Vehicle-sham group, which was inhibited by hesperetin treatment. Values are expressed as the mean ± standard deviation. *P<0.05 vs. Vehicle-sham group; #P<0.05 vs. Hesperetin-sham group; &P<0.05 vs. Vehicle-MI group. MI, myocardial infarction; CTGF, connective tissue growth factor.