Figure 4.
Effects of esculetin against DOX-induced Bmi-1 expression in H9c2 cells. (A) Effects of esculetin on Bmi-1 expression in DOX-induced H9c2 cells, compared with the DOX (**P<0.01). (B) Effects of Bmi-1 siRNA on Bmi-1 expression in each group. (C) Effects of Bmi-1 siRNA on cell apoptosis in each group. (D) Effects of Bmi-1 siRNA on ROS levels in each group, compared with the blank siRNA group (**P<0.01). DOX, doxorubicin; ROS, reactive oxygen species.