Table II.
Genotype and allele frequencies of inwardly rectifying K+ channel, subfamily J, member-11 and β1 subunit of large-conductance Ca2+-activated K+ channel SNPs.
| SNP | Gene | EH (n=267) | NT (n=259) | P-value | χ2 | OR | 95% CI |
|---|---|---|---|---|---|---|---|
| rs2285676 | Genotype | ||||||
| CC | 11 (4.12%) | 18 (6.95%) | |||||
| CT | 131 (49.06%) | 106 (40.93%) | |||||
| TT | 125 (46.82%) | 135 (52.12%) | |||||
| CT+TT | 256 (95.88%) | 241 (93.05%) | 0.155 | 2.02 | 0.58 | 0.27–1.24 | |
| Allele | |||||||
| C | 153 (28.65%) | 142 (27.41%) | |||||
| T | 381 (71.35%) | 376 (72.59%) | 0.655 | 0.20 | 1.06 | 0.81–1.39 | |
| rs5219 | Genotype | ||||||
| GG | 93 (34.83%) | 53 (20.46%) | |||||
| GA | 142 (53.18%) | 181 (69.88%) | |||||
| AA | 32 (11.99%) | 25 (9.66%) | |||||
| GA+AA | 174 (65.17%) | 206 (79.54%) | <0.01 | 13.54 | 2.08 | 1.40–3.08 | |
| Allele | |||||||
| G | 328 (61.42%) | 287 (55.41%) | |||||
| A | 206 (38.58%) | 231 (44.59%) | 0.048 | 3.92 | 1.28 | 1.00–1.64 | |
| rs11739136 | Genotype | ||||||
| CC | 187 (70.04%) | 165 (63.71%) | |||||
| CT | 67 (25.09%) | 76 (29.34%) | |||||
| TT | 13 (4.87%) | 18 (6.95%) | |||||
| CT+TT | 80 (29.96%) | 94 (36.29%) | 0.123 | 2.38 | 1.33 | 0.93–1.92 | |
| Allele | |||||||
| C | 441 (82.58%) | 406 (78.38%) | |||||
| T | 93 (17.42%) | 112 (21.62%) | 0.085 | 2.97 | 1.31 | 0.96–1.78 |
SNP, single nucleotide polymorphism; EH, essential hypertension; NT, normaltensive; OR, odds ratio; CI, confidence interval.