Table II.
Enriched GO terms in the gene interaction network.
| A, Week 1 | ||
|---|---|---|
| Term | Genes | P-value |
| GO:0010033 response to organic substance | CYP2B2, GATM, SI, RHOQ, ADH7, BRCA1, AFP, CCNE1, PLA2G4A, ABCB1B, APOA5, CYP2D4V1, RYR2, GNG5, CASQ1, SELE, NCOR2, PGGT1B, GHR | <0.0001 |
| GO:0006631 fatty acid metabolic process | CYP2B2, LPL, PLA2G4A, CYP2D4V1, ADH7, BRCA1, SLC27A5, GHR | <0.0001 |
| GO:0009725 response to hormone stimulus | CCNE1, CYP2B2, PLA2G4A, GATM, ABCB1B, APOA5, SI, RHOQ, GNG5, BRCA1, NCOR2, GHR | <0.0001 |
| GO:0009719 response to endogenous stimulus | CCNE1, CYP2B2, PLA2G4A, GATM, ABCB1B, APOA5, SI, RHOQ, GNG5, BRCA1, NCOR2, GHR | 0.001969 |
| GO:0022602 ovulation cycle process | AFP, CCNE1, PLA2G4A, NPY5R, NCOR2 | 0.002192 |
| GO:0042698 ovulation cycle | AFP, CCNE1, PLA2G4A, NPY5R, NCOR2 | 0.002986 |
| GO:0042592 homeostatic process | LPL, JPH2, SMAD5, MBP, GCM2, PLA2G4A, HAMP, APOA5, KCNE1, RYR2, NCOR2, SASH3, HTR2A | 0.003682 |
| GO:0019369 arachidonic acid metabolic process | CYP2B2, PLA2G4A, CYP2D4V1 | 0.004721 |
| GO:0048878 chemical homeostasis | LPL, PLA2G4A, GCM2, JPH2, HAMP, APOA5, KCNE1, RYR2, NCOR2, MBP | 0.006974 |
| GO:0042493 response to drug | CCNE1, CYP2B2, LPL, SNX27, ABCB1B, RYR2, SRD5A1, HTR2A | 0.00758 |
| GO:0042304 regulation of fatty acid biosynthetic process | PLA2G4A, APOA5, BRCA1 | 0.008354 |
| GO:0031099 regeneration | AFP, CCNE1, NOTCH2, GATM, APOA5 | 0.008868 |
| B, 4 weeks | ||
| Term | Genes | P-value |
| GO:0007601 visual perception | LRAT, RPE65, RGR, USH2A, RDH5 | <0.0001 |
| GO:0050953 sensory perception of light stimulus | LRAT, RPE65, RGR, USH2A, RDH5 | <0.0001 |
| GO:0007600 sensory perception | LRAT, RPE65, RGR, USH2A, RDH5 | 0.0199 |
| GO:0050890 cognition | LRAT, RPE65, RGR, USH2A, RDH5 | 0.029055 |
| GO:0006776 vitamin A metabolic process | LRAT, RPE65 | 0.030184 |
| GO:0016101 diterpenoid metabolic process | LRAT, RPE65 | 0.030184 |
| GO:0001523 retinoid metabolic process | LRAT, RPE65 | 0.030184 |
| C, 12 weeks | ||
| Term | Genes | P-value |
| GO:0045893 positive regulation of transcription, DNA-dependent | MSX1, VGLL2, TEAD3, FOXP3, ELL3, PAX2, RBPJL | 0.001781 |
| GO:0051254 positive regulation of RNA metabolic process | MSX1, VGLL2, TEAD3, FOXP3, ELL3, PAX2, RBPJL | 0.001862 |
| GO:0045941 positive regulation of transcription | MSX1, VGLL2, TEAD3, FOXP3, ELL3, PAX2, RBPJL | 0.003924 |
| GO:0010628 positive regulation of gene expression | MSX1, VGLL2, TEAD3, FOXP3, ELL3, PAX2, RBPJL | 0.004415 |
| GO:0045944 positive regulation of transcription from RNA polymerase II promoter | MSX1, VGLL2, TEAD3, FOXP3, ELL3, PAX2 | 0.004659 |
| GO:0008285 negative regulation of cell proliferation | MSX1, INPPL1, PTTG1, FOXP3, IGFBP3 | 0.006831 |
| GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | MSX1, VGLL2, TEAD3, FOXP3, ELL3, PAX2, RBPJL | 0.007352 |
| GO:0051173 positive regulation of nitrogen compound metabolic process | MSX1, VGLL2, TEAD3, FOXP3, ELL3, PAX2, RBPJL | 0.008442 |
| GO:0010557 positive regulation of macromolecule biosynthetic process | MSX1, VGLL2, TEAD3, FOXP3, ELL3, PAX2, RBPJL | 0.008569 |
| GO:0010273 detoxification of copper ion | MT1A, MT2A | 0.008659 |
GO, gene ontology.