Skip to main content
. 2017 Sep 19;5:e3836. doi: 10.7717/peerj.3836

Figure 1. Delayed firing in CA1 PCs.

Figure 1

(A–C) An example of moderate spike latency in response to a 150 pA current injection. The delay to first spike is close to 30 ms in control conditions (A), but increases to more than 50 ms in CA1 PCs treated with the dopamine agonist SKF83959 (B); overlap shown in (C). (D) Spike latency ranges from ∼30 to over 120 ms, depending on the amplitude of the stimulus current applied, and is increased at all stimulation amplitudes by SKF83959. Images (A–D) are from Chu et al. (2010). (E) Response of CA1 PC to current injections of −150, −50, 0, +50, and +300 pA. Note the response to +50 pA stimulation includes a delay to first spike of over 150 ms. This delay is abolished when the cell is stimulated at +300 pA. Image is from Ostrovskaya et al. (2014). (F) Firing delay is reduced in PCs undergoing a conditioning protocol. (G) Unpaired stimuli do not reduce firing delay. Images (F–G) are from Jung & Hoffman (2009). All figures reused under the terms of the Creative Commons Attribution (CC-BY) license or the Creative Commons Public Domain dedication (CC0).