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. 2017 Sep 19;5:e3836. doi: 10.7717/peerj.3836

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©2017 McKiernan and Marrone

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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(A) LTP induced by high-frequency stimulation (HFS) is larger in dorsal (filled circles) versus intermediate (open triangles) or ventral (open circles) horn PCs. Image is from Milior et al. (2016). (B) LTP induced by three trains of HFS (arrows; AKA strong tetanization protocol, STET) is reduced in aged (gray circles) versus young adult rats (black circles). Image is from Shetty, Sharma & Sajikumar (2017). (C–D) Baseline EPSPs are larger in young (C) versus aged (D) animals. Potentiation of synaptic responses is reduced or non-existent in aged animals (D). Images (C–D) are from Blalock et al. (2010). All figures reused under the CC-BY license.