Table 1.
Litter size, the number of male and female rat pups per litter, maternal weight gain during pregnancy and birth weight of the pups and weight of the young adult offspring at the neurobehavioral tests (g ± SEM).
| Variable (number of litter) | CON (N = 11) | OXY-H (N = 13) | OXY-L (N = 5) | p-Value |
|---|---|---|---|---|
| Total number of pups per litter | 13.3 (14) ± 2.9 | 12.3 (13) ± 4.4 | 14.4 (14) ± 1.5 | n.s. |
| Number of females per litter | 5.9 (6) ± 2.1 | 6.5 (7) ± 3.1 | 6.0 (6) ± 1.0 | n.s. |
| Number of males per litter | 7.4 (8) ± 3.0 | 5.8 (6) ± 2.5 | 8.4 (8) ± 0.5 | n.s. |
| Maternal weight gain during pregnancy, mean ± SEM (g) | 153 ± 7.3* | 113.4 ± 10.0*# | 156.1 ± 9.0# | *p = 0.01, CON vs OXY-H, diff 39.7 g #p = 0.023, OXY-H vs OXY-L, diff 42.8 g |
| Birth weight, mean ± SEM (g) | ||||
| Male (M) | M:6.4 ± 0.2 | M: 6.2 ± 0.3 | M: 6.1 ± 0.4 | n.s. |
| Female (F) | F: 6.0 ± 0.2 | F: 5.8 ± 0.3 | F: 5.6 ± 0.5 | n.s. |
| Body weight during neurobehavioral tests (adult) | M: 223 ± 6.7 | M: 250 ± 1.5 | M: 210 ± 8.0 | n.s. |
| F: 169 ± 5.4 | F: 177 ± 3.5 | F: 175 ± 4.9 | ||
CON, control; OXY-H, oxycodone high dose; OXY-L, oxycodone low dose.