Table 1.
AMP | Coating type1 | Surface2 | Antimicrobial activity | References |
---|---|---|---|---|
Bacitracin | Surface tethering | Titanium | Reduction surface adhesion by S. aureus in vitro, and reduction implant and tissue colonization by S. aureus in a rat femur implant infection model | Nie et al., 2016, 2017 |
Chimeric peptidea | Binding domain | Titanium | Surface bactericidal activity against Streptococcus gordonii and S. sanguinise in vitro | Liu et al., 2016 |
Chimeric peptideb | Binding domain | Titanium | Reduction surface adhesion by Streptococcus mutans, S. epidermidis, and E. coli in vitro | Yucesoy et al., 2015; Yazici et al., 2016 |
E6 | Polymer brushes | PU | Reduction catheter surface colonization by P. aeruginosa, S. aureus, and Staphylococcus saprophyticus in vitro and by P. aeruginosa in mouse urinary catheter infection model | Yu et al., 2017 |
GL13K | Surface tethering | Titanium | Surface bactericidal activity against S. gordonii and Porphyromonas gingivalis in vitro | Chen et al., 2014; Zhou et al., 2015 |
GZ3.27c | Surface tethering | Titanium, glass, silicon | Surface bactericidal activity against P. aeruginosa and E. coli in vitro | De Zoysa and Sarojini, 2017 |
hLF1-11 | Polymer brushes | Titanium | Surface bactericidal activity against S. sanguinis and Lactobacillus salivarius in vitro | Godoy-Gallardo et al., 2015 |
hLF1-11 | Surface tethering | Titanium, chitosan | Reduction surface colonization by S. aureus (both surfaces) and S. sanguinis (chitosan) in vitro | Costa et al., 2014; Hoyos-Nogués et al., 2017 |
Inverso-CysHHC10 | Hydrogel | PET | Surface bactericidal activity against S. aureus, S. epidermidis, and E. coli in vitro | Cleophas et al., 2014 |
Magainin I | Self-assembling silk | PS | Reduction surface adhesion by S. aureus in vitro | Nilebäck et al., 2017 |
Melimine | Surface tethering | Titanium | Reduction surface adhesion by P. aeruginosa in vitro, and reduction implant and tissue colonization by S. aureus in mouse and rat subcutaneous implant infection | Chen et al., 2016 |
Melimine, Mel-4, LFcd, LL-37 | Surface tethering | pHEMA | Surface bactericidal activity against P. aeruginosa (LL-37, Mel-4, and Melimine) and S. aureus (Mel-4 and Melimine) in vitro | Dutta et al., 2016 |
SESB2V | Surface tethering | Titanium | Reduction tissue colonization by S. aureus and P. aeruginosa in a rabbit keratitis model | Tan et al., 2014 |
Tet20 | Polymer brushes | Titanium | Surface bactericidal activity against P. aeruginosa and S. aureus in vitro, reduction surface adhesion by S. aureus in rat subcutaneous implant infection | Gao et al., 2011a |
Tet213 | Polymer brushes | Titanium | Surface bactericidal activity against P. aeruginosa in vitro | Gao et al., 2011b |
Surface tethering by covalent immobilization of AMP to surface; Chimeric peptide consists of titanium-binding domain and antimicrobial motif.
PET, polyethylene terephthalate; PU, polyurethane; pHEMA, poly-hydroxyethylmethacrylate; PS, polystyrene.
Chimeric peptides consist of minTBP-1 and JPH8194 motifs.
Chimeric peptides consist of TiBP(S)1–3 and E14LKK/H14LKK or KWKRWWWWR motifs.
GZ3.27 with an added N-terminal cysteine is designated GZ3.163.
LFc, lactoferricin.
Formally known as Streptococcus sanguis, as mentioned in the reference.