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. Author manuscript; available in PMC: 2017 Sep 22.
Published in final edited form as: Nat Immunol. 2015 Jun 1;16(7):729–736. doi: 10.1038/ni.3196

Figure 4. TFBE regulates MHC Class II antigen presentation in BMDCs.

Figure 4

(a) MHC class II mediated antigen presentation in TFEB-transduced BMDCs following exposure to HEL-coated beads. (b) The effect of TFEB silencing on the LPS-induced enhancement of MHC class II antigen presentation in BMDCs. (c) The effect of TFEB silencing on MHC class II antigen presentation of HEL by macrophages. (d-f) The role of TFEB in the translocation of MHC class II molecules (I-Ab) to the surface of BMDCs is evaluated by confocal microscopy and flow cytometry. For all panels unless otherwise indicated the data represents the mean ± SE from at least three independent experiments (cells isolated from at least three different mice), unless otherwise indicated. *P < 0.05 (Student's t-test).