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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Br J Haematol. 2015 Dec 21;175(3):542–545. doi: 10.1111/bjh.13877

Figure 2. BCR-FGFR1 dysregulates multiple signaling pathways related to myeloid cell development and differentiation.

Figure 2

(A) Real-time RT-PCR analysis shows transcription level changes for selected genes related to myeloid development and differentiation in the primary recipients (primers specifically recognize human genes, left panel). (B) Western blot analysis shows the changes of downstream components of the FGFR1 signaling pathway as well as protein levels of GFI1, MYC, and BCL-2/BCL-xL in leukemic mouse spleens compared with normal human peripheral blood mononuclear cells (PBMC). (C) Scheme of the molecular mechanism of BCR-FGFR1-induced AML in the mouse model.