Table 15. Performance comparison results of clustering and biological metrics in HPRD and Biogrid-human.
| Approach | #C | FM | Acc | MMR | GoSim | Coloc. | SC | Time(s) |
|---|---|---|---|---|---|---|---|---|
| HPRD | PCDq | |||||||
| DAPG | 2,777 | 0.3431 | 0.2992 | 0.1681 | 0.9225 | 0.4192 | 0.6564 | 30.78 |
| ClusterONE | 2,186 | 0.2923 | 0.5122 | 0.1718 | 0.7735 | 0.4106 | 0.3114 | 4.6 |
| MCL | 1,248 | 0.2167 | 0.4717 | 0.1120 | 0.7430 | 0.3831 | 0.4150 | 10.39 |
| CFinder | 416 | 0.1637 | 0.2935 | 0.0598 | 0.6283 | 0.3284 | 0.2383 | 12.42 |
| DCAFP | 123 | 0.1185 | 0.1654 | 0.0086 | 0.8532 | 0.3440 | 0.8848 | 25,470.12 |
| RNSC | 1,081 | 0.2250 | 0.4445 | 0.1122 | 0.8235 | 0.4241 | 0.3862 | 2.32 |
| MCODE | 16 | 0.0170 | 0.1003 | 0.0041 | 0.8033 | 0.5806 | 0.6553 | 10.23 |
| SPICI | 722 | 0.2410 | 0.4148 | 0.0835 | 0.7856 | 0.3801 | 0.4510 | 0.82 |
| COREPEEL | 3,420 | 0.3577 | 0.2943 | 0.1852 | 0.9249 | 0.4074 | 0.6667 | 1.01 |
| DSDCluster | 1,247 | 0.2012 | 0.4181 | 0.0994 | 0.7389 | 0.3874 | 0.5405 | 3.8 hrs. |
| CORUM | ||||||||
| DAPG | 2,777 | 0.3685 | 0.2119 | 0.2066 | ||||
| ClusterONE | 2,186 | 0.1348 | 0.3162 | 0.0730 | ||||
| MCL | 1,248 | 0.1048 | 0.3042 | 0.0488 | ||||
| CFinder | 416 | 0.0769 | 0.1982 | 0.0270 | ||||
| DCAFP | 123 | 0.1490 | 0.1460 | 0.0270 | ||||
| RNSC | 1,081 | 0.1234 | 0.2773 | 0.0565 | ||||
| MCODE | 16 | 0.0154 | 0.0786 | 0.0047 | ||||
| SPICI | 722 | 0.1095 | 0.2566 | 0.0357 | ||||
| COREPEEL | 3,420 | 0.4017 | 0.2131 | 0.2360 | ||||
| DSDCluster | 1,247 | 0.1056 | 0.2671 | 0.0510 | ||||
| CORUM, PCDq | ||||||||
| DAPG | 2,777 | 0.4757 | 0.1987 | 0.1788 | ||||
| ClusterONE | 2,186 | 0.2887 | 0.3485 | 0.1101 | ||||
| MCL | 1,248 | 0.1936 | 0.3233 | 0.0701 | ||||
| CFinder | 416 | 0.1166 | 0.2036 | 0.0368 | ||||
| DCAFP | 123 | 0.0898 | 0.1161 | 0.0155 | ||||
| RNSC | 1,081 | 0.2080 | 0.3010 | 0.0743 | ||||
| MCODE | 16 | 0.0094 | 0.0652 | 0.0027 | ||||
| SPICI | 722 | 0.1946 | 0.2761 | 0.0506 | ||||
| COREPEEL | 3,420 | 0.5168 | 0.1970 | 0.2033 | ||||
| DSDCluster | 1,247 | 0.1884 | 0.2837 | 0.0661 | ||||
| Biogrid Human | PCDq | |||||||
| DAPG | 7,409 | 0.1599 | 0.3495 | 0.1272 | 0.8213 | 0.4041 | 0.5443 | 620.32 |
| ClusterONE | 4,254 | 0.0863 | 0.4802 | 0.0653 | 0.6476 | 0.4008 | 0.2532 | 201.32 |
| MCL | 1,433 | 0.0431 | 0.3594 | 0.0190 | 0.6225 | 0.3695 | 0.2392 | 54.21 |
| RNSC | 2,194 | 0.0774 | 0.4491 | 0.0502 | 0.8235 | 0.3971 | 0.2206 | 35.23 |
| MCODE | 20 | 0.0063 | 0.0883 | 0.0013 | 0.8312 | 0.3695 | 0.5262 | 475.23 |
| SPICI | 1,063 | 0.0803 | 0.3784 | 0.0263 | 0.6763 | 0.3729 | 0.3829 | 1.01 |
| COREPEEL | 9,772 | 0.1995 | 0.3200 | 0.1550 | 0.8468 | 0.4059 | 0.5782 | 10.83 |
| DSDCluster | 1,593 | 0.0610 | 0.3673 | 0.0307 | 0.6344 | 0.3601 | 0.4148 | 5.5 hrs. |
| CORUM | ||||||||
| DAPG | 7,409 | 0.2527 | 0.2917 | 0.2539 | ||||
| ClusterONE | 4,254 | 0.0529 | 0.3625 | 0.0417 | ||||
| MCL | 1,433 | 0.0403 | 0.2610 | 0.0179 | ||||
| RNSC | 2,194 | 0.0637 | 0.3632 | 0.0418 | ||||
| MCODE | 20 | 0.0105 | 0.1046 | 0.0032 | ||||
| SPICI | 1,063 | 0.0643 | 0.3013 | 0.0235 | ||||
| COREPEEL | 9,772 | 0.3477 | 0.2778 | 0.3063 | ||||
| DSDCluster | 1,593 | 0.0824 | 0.3118 | 0.0409 | ||||
| CORUM, PCDq | ||||||||
| DAPG | 7,409 | 0.3002 | 0.2585 | 0.1847 | ||||
| ClusterONE | 4,254 | 0.1020 | 0.3709 | 0.0485 | ||||
| MCL | 1433 | 0.0512 | 0.2655 | 0.0165 | ||||
| RNSC | 2,194 | 0.0921 | 0.3596 | 0.0402 | ||||
| MCODE | 20 | 0.0069 | 0.0878 | 0.0018 | ||||
| SPICI | 1,063 | 0.0836 | 0.2899 | 0.0217 | ||||
| COREPEEL | 9,772 | 0.3965 | 0.2414 | 0.2250 | ||||
| DSDCluster | 1,593 | 0.0848 | 0.2904 | 0.0305 | ||||