Table 1. Histological characteristics and expression of LAT1 in brain tumours.

Case	Tumour type	Primitive site	Sample size	LAT1 score	Predominant subcellular localization	Vessels n/HPF	LAT1 staining intensity in vessels
1	Metastasis	breast	L	160	Cytoplasm	21	weak
2	Metastasis	lung	L	180	Membrane	6	moderate
3	Glioblastoma		L	190	Mixed	14	weak
4	Glioblastoma		L	100	Mixed	1	moderate
5	Oligo II		L	100	Mixed	9	weak
6	Glioblastoma		L	165	Cytoplasm	12	strong
7	Oligo II		L	240	Cytoplasm	6	weak
8	Glioblastoma		S	50	Mixed	11	moderate
9	Glioblastoma		L	180	Cytoplasm	9	weak
10	Metastasis	ovary	L	400	Mixed	16	weak
11	Glioblastoma		L	400	Mixed	28	weak
12	Metastasis	esophagus	L	400	Mixed	12	weak
13	Glioblastoma		L	150	Mixed	11	weak
14	Metastasis	lung	L	180	Cytoplasm	22	weak
15	Metastasis	lung	S	300	Cytoplasm	8	weak
16	Glioblastoma		L	285	Mixed	7	moderate
17	Metastasis	lung	L	270	Mixed	6	weak
18	Glioblastoma		S	300	Mixed	8	weak
19	Glioblastoma		S	160	Mixed	11	weak
20	Metastasis	breast	L	285	Mixed	17	weak
21	Oligoastro III		L	130	Mixed	13	moderate
22	Glioblastoma		S	40	Mixed	22	moderate
23	Metastasis (radionecrosis)	melanoma	L	20	Cytoplasm	18	weak
24	Oligoastro II		L	30	Mixed	5	weak
25	Oligoastro II		S	20	Mixed	4	weak
26	Astro II (inflammation)		L	90	Mixed	25	weak
27	Glioblastoma		L	160	Mixed	7	strong
28	Glioblastoma		L	200	Mixed	21	moderate

Oligo: oligodendroglioma, Oligoastro: Oligoastrocytoma, Astro: Astrocytoma. II: Grade II, III: Grade III. S: less than 1 cm³; L: more than 1 cm³. n/HPF: mean number of vessels per high power field (x400)